BDBM50029050 (-)-(R)-epinephrine::(-)-3,4-dihydroxy-alpha-((methylamino)methyl)benzyl alcohol::(-)-adrenaline::(R)-(-)-adrenaline::(R)-adrenaline::4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol::Adrenalin::CHEMBL679::EPINEPHRINE::adrenaline::levoepinephrine
SMILES CNC[C@H](O)c1ccc(O)c(O)c1
InChI Key InChIKey=UCTWMZQNUQWSLP-VIFPVBQESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 38 hits for monomerid = 50029050
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
National Institute Of Diabetes
Curated by ChEMBL
National Institute Of Diabetes
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Binding affinity against alpha 2-Adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]clonidineMore data for this Ligand-Target Pair
3D Structure (crystal)TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 38nMAssay Description:Displacement of [3H]clonidine from adrenergic alpha 2 receptor of rat cerebral cortical membranesMore data for this Ligand-Target Pair
Affinity DataKi: 160nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 200nMAssay Description:Compound was evaluated for inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat forebrain homogenate.More data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Friedrich-Alexander University
Curated by ChEMBL
Friedrich-Alexander University
Curated by ChEMBL
Affinity DataKi: 360nMAssay Description:Displacement of [3H]CGP12177 from human beta2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Canis familiaris)
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 660nMAssay Description:Binding of [3H]-dihydroalprenolol to beta-2 adrenergic receptor of rat cerebral cortical membranesMore data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Rattus norvegicus)
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 720nMAssay Description:Binding affinity against adrenergic beta 2 receptor versus 1 nM [3H]dihydroalprenolol in rat cerebral cerebellar membranesMore data for this Ligand-Target Pair
Affinity DataKi: 910nMAssay Description:Displacement of [3H]spiperone from human D2S receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetBeta-1 adrenergic receptor(Rattus norvegicus (Rat))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 1.10E+3nMAssay Description:Binding of [3H]-dihydroalprenolol to beta-1 adrenergic receptor of rat cerebral cortical membranesMore data for this Ligand-Target Pair
TargetBeta-1 adrenergic receptor(Rattus norvegicus (Rat))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 1.20E+3nMAssay Description:Displacement of [3H]dihydroalprenolol from adrenergic beta 1 receptor of rat cerebral cortical membranesMore data for this Ligand-Target Pair
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
National Institute Of Diabetes
Curated by ChEMBL
National Institute Of Diabetes
Curated by ChEMBL
Affinity DataKi: 2.00E+3nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101More data for this Ligand-Target Pair
Affinity DataKi: 2.40E+3nMAssay Description:Displacement of [3H]WB-4101 from adrenergic alpha 1 receptor of rat cerebral cortical membranesMore data for this Ligand-Target Pair
Affinity DataKi: 3.00E+3nMAssay Description:Binding affinity against beta-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of Dihydro-[3H]-alprenololMore data for this Ligand-Target Pair
Affinity DataKi: 4.00E+3nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid libraryMore data for this Ligand-Target Pair
Affinity DataKi: 1.19E+6nMAssay Description:TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.60E+6nMAssay Description:TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing MDCK cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 30nMAssay Description:Agonist activity at recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane incubated for 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 31nMAssay Description:Agonist activity at human adrenergic beta-3 receptor expressed in CHO cells assessed as cAMP levels by DELFIA methodMore data for this Ligand-Target Pair
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
National Institute Of Diabetes
Curated by ChEMBL
National Institute Of Diabetes
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranesMore data for this Ligand-Target Pair
TargetBeta-1/Beta-2/Beta-3 adrenergic receptor(Rattus norvegicus (Rat))
National Institute Of Diabetes
Curated by ChEMBL
National Institute Of Diabetes
Curated by ChEMBL
Affinity DataEC50: 230nMAssay Description:Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pi...More data for this Ligand-Target Pair
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
National Institute Of Diabetes
Curated by ChEMBL
National Institute Of Diabetes
Curated by ChEMBL
Affinity DataEC50: 400nMAssay Description:Beta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparationsMore data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Friedrich-Alexander University
Curated by ChEMBL
Friedrich-Alexander University
Curated by ChEMBL
Affinity DataKd: 630nMAssay Description:Binding affinity to human adrenergic beta2 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 49nMAssay Description:Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as [3H]cAMP levels by radiolabeled ligand based assayMore data for this Ligand-Target Pair
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
National Institute Of Diabetes
Curated by ChEMBL
National Institute Of Diabetes
Curated by ChEMBL
Affinity DataEC50: 300nMAssay Description:Agonistic potency at alpha 2-Adrenergic receptor for inhibition of 10 uM forskolin-elicited stimulation of adenylate cyclase in human platelet membra...More data for this Ligand-Target Pair
TargetAlpha-1A adrenergic receptor/Alpha-1B adrenergic receptor/Alpha-1D adrenergic receptor/Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(Rattus norvegicus (rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Binding affinity against Alpha adrenergic receptor using [3H]dihydroergocryptine radioligand in rat brain homogenateMore data for this Ligand-Target Pair
TargetBeta-1/Beta-2/Beta-3 adrenergic receptor(Rattus norvegicus (Rat))
National Institute Of Diabetes
Curated by ChEMBL
National Institute Of Diabetes
Curated by ChEMBL
Affinity DataIC50: 2.90E+4nMAssay Description:Binding affinity against Beta adrenergic receptor using [3H]dihydroalprenolol radioligand in rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataEC50: 436nMAssay Description:Effective dose required to stimulate contractions in isolated guinea pig atrium.More data for this Ligand-Target Pair
TargetBeta-1/Beta-2/Beta-3 adrenergic receptor(Rattus norvegicus (Rat))
National Institute Of Diabetes
Curated by ChEMBL
National Institute Of Diabetes
Curated by ChEMBL
Affinity DataEC50: 230nMAssay Description:Stimulation of cyclic AMP accumulation in C6 glioma cells expressing adrenergic beta receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Effective dose for relaxation of guinea pig trachea.More data for this Ligand-Target Pair
Affinity DataEC50: 260nMAssay Description:Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaMore data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Friedrich-Alexander University
Curated by ChEMBL
Friedrich-Alexander University
Curated by ChEMBL
Affinity DataKd: 631nMAssay Description:Binding affinity to beta-2 adrenergic receptor (unknown origin) at 1 to 10000 nMMore data for this Ligand-Target Pair
Affinity DataEC50: 75nMAssay Description:Agonist activity at human alpha1 beta adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by m...More data for this Ligand-Target Pair
Affinity DataEC50: 290nMAssay Description:Agonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuri...More data for this Ligand-Target Pair
Affinity DataEC50: 290nMAssay Description:Agonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuri...More data for this Ligand-Target Pair
Affinity DataKd: 5.50E+4nMAssay Description:Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 75nMAssay Description:Agonist activity at human alpha1 beta adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by m...More data for this Ligand-Target Pair